2 edition of Syntheses towards carbohydrate-bearing dendrimers for novel drug delivery found in the catalog.
Syntheses towards carbohydrate-bearing dendrimers for novel drug delivery
Marianne F. A. Grossier
|Statement||Marianne F.A.Grossier ; supervised by J.M. Gardiner.|
|Contributions||Gardiner, J. M., Chemistry.|
With contributions from many of the worlds leading scientists in the field of dendritic research and development, Dendrimers and Other Dendritic Polymers provides a comprehensive review of this rapidly expanding and exciting new field of polymer science. Of interest to academia and industry alike, this book covers the synthesis, characterization, unique properties, potential for novel. While such dendrimers modified with charged groups have found use in biomedical applications such as drug delivery, sensing, and MRI contrast agents, the design and control over the synthesis of these dendrimers remains challenging and is still subject to further optimization. So far, only partially zwitterionic dendrimers (ZIDs) (modification.
Synthesis of novel rigid rod iron metal containing polyyne polymers. Porphyrin and Phthalocyanine Ring Structures”, in Dendrimer Chemistry: Synthetic approaches towards complex architectures, Book Series: Monographs in Supramolecular Chemistry, Royal Society of Chemistry, Cambridge, UK, , Chapter 7, Maysinger, D.; Kakkar. Dendrimers and hyperbranched polymers are hot topics which have attracted broad and persistent interest from both academic and industrial researchers due to their unique three-dimensional highly-branched topologies, multi-functionalities, special chemical and physical properties, and potential applications as catalysts, as materials, and for biology.
used to prepare self-assembled polymer micelles for drug delivery,9,15,16 although the use of graft copolymers has been reported For drug delivery purposes, the individual ure designed to be nimers a biodegradable20, 21 and/or have a low enough molecular mass . Non-bilayer lipids used in drug delivery. In many biological systems, the major lipids are non-bilayer lipids, which in purified form cannot be arranged in a lamellar structure in the presence of aqueous systems. The structural and functional roles of these lipids in drug delivery are mainly in their utilization as matrix-forming lipids.
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Synthesis. Dendrimers are just in between molecular chemistry and polymer chemistry. They relate to the molecular chemistry world by virtue of their step-by-step controlled synthesis, and they relate to the polymer world because of their repetitive structure made of monomers .The three traditional macromolecular architectural classes (i.e., linear, Cited by: This review provides brief information concerning with the dendrimer, its synthesis, characterization and application in drug delivery.
Dendrimer consist of well defined size, shape, molecular weight and monodispersity. These properties formulate the dendrimers a suitable carrier in drug delivery application. Dendrimer are built. Hsieh-Chih Tsai, Toyoko Imae, in Progress in Molecular Biology and Translational Science, C Delivery of Drugs Loaded by Chemical Binding in Dendrimers.
Dendrimer –drug conjugates generally consist of drugs covalently attached to the periphery of the dendrimer. This type of drug carrier offers different advantages over physically encapsulated drug carrier systems.
Functionalization of the peripheral groups of dendrimers is a fruitful and convenient strategy for developing novel functional material for biomedical applications, and ways to simplify the synthesis toward achieving would be beneficial.
42 For biomedical and drug delivery applications of dendrimers, there is a need to develop these scaffolds Cited by: DENDRIMERS: SYNTHESIS, PROPERTIES, BIOMEDICAL AND DRUG DELIVERY APPLICATIONS. Overall, dendrimers are most important macro-molecules in the novel drug delivery system and they have various pharmaceutical as well as non-pharmaceutical applications.
View. These fundamental properties have led to the commercial use of PAMAM dendrimers as globular protein replacements for immunodiagnost 24, 25 and in vitro gene expression applications [Qiagen (Chatsworth, CA, USA; ) Transfection Resource Book ].
Although there are many similarities between dendrimers and globular proteins. SYNTHESES (DRUG DERIVATIZATION) General Methods of Dendrimer Synthesis Dendrimers can be considered to have three major portions: a core, an inner shell, and an outer shell.
Ideally a dendrimer can be synthesized to have different functionality in each of these portions to control properties such as solubility, thermal stability, and attachment. Of interest to academia and industry alike, this book covers the synthesis, characterization, unique properties, potential for novel applications and technical challenges associated with these polymers.
* Detailed coverage of all known subclasses of dendritic polymers, including their properties and synthesis. This book explores the use of dendrimers for a variety of potential functions, including antiamyloidogenic agents, drug delivery systems, nucleic acid and RNA delivery vectors and to produce hybrid fibre platforms for nantechnology.
D Emanuele A, Attwood mer-drug interactions. Adv. Drug Delivery Rev. ; David Owen and Paul Barrett. Dendrimers enhance delivery of small molecule and biological drugs: control solubility, half-life, toxicity and targeting.
[ONLINE] Available at. Starting from 4-amino(tert-butoxycarbonyl)piperidine (Boc-PD-NH2), we report the synthesis of three novel meta-tri- and dimeric tetravalent N-substituted melamines with. Edited “Advances in controlled and novel drug delivery. CBS publisher and distributors, New Delhi, Edition 1, Tomalia DA, Berry V, Hall M, and Headstrand DM: Macromolecules ; Pushkar S, Philip A, Pathak K and Pathak D: Dendrimers: Nanotechnology Derived Novel Polymers in Drug Delivery.
Cancer treatment with small interfering RNA (siRNA) is one of the most promising new strategies; however, transfection systems that increase its bioavailability and ensure its delivery to the target cell are necessary.
Transfection systems may be just vehicular or could contain fragments with anticancer activity that achieves a synergistic effect with siRNA.
Cationic carbosilane dendrimers. Keywords:Dendrimers, porphyrin, phthalocyanine, photomedicine, photodynamic therapy, photodiagnostic. Abstract:In medical applications such as drug delivery, gene transfection and imaging the formation of systems with well-defined sizes and shapes are of significant interest.
For this reason the design of dendrimers with modulated size, shape. Multivalent protein−carbohydrate interactions mediate a wide variety of intercellular recognition processes with high selectivity and specificity. Many synthetic multivalent molecules have been designed to mimic and to inhibit these processes.
Using carbohydrate functionalized dendrimers, our goal is to devise a system where the binding activity and the degree of protein clustering. Dendrimers and their Applications as Novel Drug Delivery Carriers Surendra Tripathy1* 2and Malay K Das 1 Division of Pharmaceutics, Varanasi College of Pharmacy, Varanasi, India.
2Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, India. ARTICLE INFO ABSTRACT Article history: Received on: 24/07/ He, D.; Guo, L. Design and synthesis of novel amphiphilic Janus dendrimers for bone-targeted drug delivery.
Tetrahedron,68(14), A Novel Strategy Towards Aminophosphonic Derivatives Based on the Diels-Alder Cycloaddition: Experimental and Theoretical Approaches.
Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer.
As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and. Nanocarriers for drug delivery.
Nanomedicine is a rapidly developing area that is revolutionizing cancer diagnosis and therapy. Nanoparticles have unique biological properties given their small. The unique structures and properties of dendrimers make them attractive for many applications, from drug delivery and antimicrobial agents to catalysis and as functional materials.
Dendrimer Chemistry provides an overview of the latest advances in the synthesis of dendrimers and other complex dendritic architectures. The book focuses on established .Johnson, E., Kent, S.: Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-α-thioester building blocks.
Tetrahedron Lett. 48 (10), – () PubMed CrossRef Google Scholar.Nano- and Microscale Drug Delivery Systems: Design and Fabrication presents the developments that have taken place in recent years in the field of micro- and nanoscale drug delivery systems.
Particular attention is assigned to the fabrication and design of drug delivery systems in order to i) reduce the side effects of therapeutic agents, ii) increase their .